Conan O'Brien's final show as host of "The Tonight Show" features Tom Hanks and Will Ferrell, who had been guests on his first two shows, along with a variety of surprise guests.

GameSpot may receive revenue from affiliate and advertising partnerships for sharing this content and from purchases through links. Comedian and host Conan O'Brien's "Clueless Gamer" segment is back, ...

On Saturday night, comedy stars Conan O’Brien, Sarah Silverman, Sebastian Maniscalco, and more joined host Denis Leary for the 29th edition of Comics Come Home. For O’Brien, who grew up in Brookline, ...

Sometimes gallows humor is the best medicine. On this week’s episode of Conan O’Brien’s podcast “Conan O’Brien Needs A Friend,” guest and longtime Conan buddy Will Arnett told an amazing tale. When ...