(A) UMAP visualization of the 13,363 chondrocytes from healthy human cartilage. Color represents the chondrocyte subset. (B) UMAP visualization of the expression of representative marker genes for ...

“This study provides novel insights into the pathogenesis of OA and suggests a potential therapeutic target in OA treatment.” The concept of osteoarthritis (OA) as a low-grade inflammatory joint ...

An x-ray of a pair of hands showing painful joints The role of micro-RNAs in the pathophysiology of hand osteoarthritis was explored, using data from postmenopausal women. Micro-RNAs may serve as ...

Chondrocytes are specialized cells that are essential for cartilage maintenance and repair, and their dysfunction is central to the development of joint diseases like osteoarthritis (OA). However, the ...

GNSC-001 is an investigational, adeno-associated virus gene therapy expressing an optimized form of IL-1Ra. The Food and Drug Administration (FDA) has granted Fast Track designation to GNSC-001 for ...

Objective: To compare the short-term efficacy and tolerability of an oral enzyme therapy with the NSAID diclofenac in patients with symptomatic osteoarthritis of the knee (gonarthritis). Methods: In a ...

Tricompartmental osteoarthritis causes pain and damage due to the cartilage (cushioning) in a joint breaking down. This form of osteoarthritis occurs when there's damage in the three compartments of ...

Please provide your email address to receive an email when new articles are posted on . Although osteoarthritis is receiving more attention in both the research and clinical arenas than ever, all that ...

In a recent study published in The Lancet EBioMedicine, a team of scientists used Mendelian Randomization analyses to explore whether antidiabetic medications could potentially be used as ...